Image

Alliance Française contre les Maladies Parasitaires

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

Monday, 14 November 2022

[Communiqué] Gerald Spaeth, chef de l'unité "Parasitologie moléculaire et signalisation" à L'institut pasteur Paris, a obtenu une subvention Synergy du Conseil européen de la...

Monday, 02 November 2015

The Nobel Prize in Medicine 2015 was awarded to researchers in epidemiology : William Campbell (Ireland), Satoshi Omura (Japan) and Youyou Tu (China). They were rewarded for their work against...

Home PIs Yvon Sterkers

 

  YS

 

Yvon STERKERS

Information
microscope MIVEGEC 
team Biologie, Génétique et Pathologie des Pathogènes Eucaryotes 
location Montpellier
orcid 0000-0002-5623-5664 
email This email address is being protected from spambots. You need JavaScript enabled to view it.
website https://mivegec.fr/

Scientific interests and projects

The team's interest relies in the molecular and cell biology of protozoan parasites, with a focus on Trypanosomatids (Leishmania and Trypanosoma brucei). More precisely, we seek to elucidate the mechanisms of basic biological processes of the parasite cell which are 'divergent' from classical eukaryotic models – and more specifically related to mitosis, e.g. DNA replication, chromosomal segregation, recombination, spindle assembly, cell division …

One of the great conceptual achievements of the group over the last 10 years has been the demonstration of a constitutive so-called 'mosaic aneuploidy' in Leishmania, which, even if exaggerated in in vitro conditions (as opposed to the 'real life' of the parasite), questions its astonishing ability to generate and tolerate aneuploidy. This may be related to a greater tolerance to mis-replication or to some degree of 'permissive' segregation – and this is still being elucidated.

More on the 'cell biology' side, the team takes interest into microtubular structures and microtubule-associated proteins, which are deeply involved in events such as cell growth and cell division. Present projects focus on the role of post-translational modifications of microtubules and that of kinesins in cell division.

For these studies, the group has developed novel molecular tools, in particular the first efficient CRISPR-Cas9 strategy in Leishmania and more recently, has set up an efficient and straightforward approach for inducible knock-outs, opening for the first time the way to the study of essential genes in this parasite. It also takes advantage of the mastering by the team of two demanding techniques, DNA molecular combing and FISH, as well as obviously, more 'classical' approaches such as microscopy and imaging, WGS, ChIP, etc.

Collaborations are open about (i) these matters/models with different view angles or technological approaches, or (ii) different models of which the study would benefit from technical approaches not necessarily mastered in the network.

Top 5 publications of the last 5 years

1. Morelle C*, Sterkers Y*°, Crobu L, MBang-Benet DE, Kuk N, Portalès P, Bastien P, Pagès M°, Lachaud L°. The nucleoporin Mlp2 is involved in chromosomal distribution during mitosis in trypanosomatids. Nucleic Acids Res. 2015 Apr 30;43(8):4013-27. *cofirst and °co-corresponding author. doi: 10.1093/nar/gkv056

2. Garcia-Silva MR, Sollelis L, MacPherson CR, Stanojcic S, Kuk N, Crobu L, Bringaud F, Bastien P, Pagès M, Scherf A, Sterkers Y. Identification of the centromeres of Leishmania major: revealing the hidden pieces. EMBO Rep. 2017 Nov;18(11):1968-1977. 10.15252/embr.201744216

3. Vergnes B, Gazanion E, Mariac C, Du Manoir M, Sollelis L, Lopez-Rubio JJ, Sterkers Y, Bañuls AL. A single amino acid substitution (H451Y) in Leishmania calcium-dependent kinase SCAMK confers high tolerance and resistance to antimony. J Antimicrob Chemother. 2019 Nov 1;74(11):3231-3239. doi: 10.1093/jac/dkz334

4. Sollelis L, Ghorbal M, MacPherson CR, Martins RM, Kuk N, Crobu L, Bastien P, Scherf A, Lopez-Rubio JJ, Sterkers Y. First efficient CRISPR-Cas9-mediated genome editing in Leishmania parasites. Cell Microbiol. 2015 Oct;17(10):1405-12. doi: 10.1111/cmi.12456

5. Stanojcic S, Sollelis L, Kuk N, Crobu L, Balard Y, Schwob E, Bastien P, Pagès M, Sterkers Y. Single-molecule analysis of DNA replication reveals novel features in the divergent eukaryotes Leishmania and Trypanosoma brucei versus mammalian cells. Sci Rep. 2016 Mar 15;6:23142. doi: 10.1038/srep23142
Friday, 16 December 2022

    PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France  A renewable 1-year postdoctoral...

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Friday, 03 June 2022

  PhD Position in Single Particle Imaging of P. falciparum Knobs Project Leader Prof. Dr. Michael Lanzer (Heidelberg University Hospital, Centre for Infectious Diseases,...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

PROGRAMME DE FORMATION

Programme Doctoral International

Workshops de formation

ACTUALITÉS

Actualités du LabEx
Autres actualités

 

CONTACT

Project Manager: Yoann MILLERIOUX
Contact

Twitter Social Icon Rounded Square Color @ParaFrap #ParaFrap

Cookies settings

×

Functional Cookies

Ce site utilise des cookies pour assurer son bon fonctionnement et ne peuvent pas être désactivés de nos systèmes. Nous ne les utilisons pas à des fins publicitaires. Si ces cookies sont bloqués, certaines parties du site ne pourront pas fonctionner.

Measure of audience

Ce site utilise des cookies de mesure et d’analyse d’audience, tels que Google Analytics et Google Ads, afin d’évaluer et d’améliorer notre site internet.

Interactive Content

Ce site utilise des composants tiers, tels que NotAllowedScript6949bac7e6b4aReCAPTCHA, Google NotAllowedScript6949bac7e63d1Maps, MailChimp ou Calameo, qui peuvent déposer des cookies sur votre machine. Si vous décider de bloquer un composant, le contenu ne s’affichera pas

Social Networks / Videos

Des plug-ins de réseaux sociaux et de vidéos, qui exploitent des cookies, sont présents sur ce site web. Ils permettent d’améliorer la convivialité et la promotion du site grâce à différentes interactions sociales.

Session

Please login to see yours activities!

Other cookies

Ce site web utilise un certain nombre de cookies pour gérer, par exemple, les sessions utilisateurs.