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Alliance Française contre les Maladies Parasitaires

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

Monday, 14 November 2022

[Communiqué] Gerald Spaeth, chef de l'unité "Parasitologie moléculaire et signalisation" à L'institut pasteur Paris, a obtenu une subvention Synergy du Conseil européen de la...

Monday, 02 November 2015

The Nobel Prize in Medicine 2015 was awarded to researchers in epidemiology : William Campbell (Ireland), Satoshi Omura (Japan) and Youyou Tu (China). They were rewarded for their work against...

Home JOBS PostDoc l Biological Sciences l Strasbourg

PostDoc l Biological Sciences l Strasbourg

  17 universite strasbourg 

PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France 

A renewable 1-year postdoctoral position is open at IBMC (Inserm/CNRS/University of Strasbourg) to investigate the mode of action of novel and promising antimalarial benzylmenadiones with potent curing and transmission blocking activities. This project is based on a combination of complementary strategies, notably genetics, activity-based protein profiling and proteomics in both yeast and Plasmodium parasites, to identify putative benzylmenadione targets. Candidate targets will be validated by genetic engineering in Plasmodium, and their role in parasite biology and in mediating benzylmenadione activity will be investigated.

Project leader:

The project will be supervised by Dr. Stephanie Blandin. It is part of a French/Swiss collaborative consortium working on novel antimalarial drugs and encompassing multiple disciplines: medicinal chemistry of redox-active antiparasitic compounds (Dr. Elisabeth Davioud-Charvet at ECPM, Strasbourg), mass spectrometry analysis & proteomics (Drs. Christine Schaeffer & Jean-Marc Strub at IPHC, Strasbourg), parasitology and drug screening (Profs. Pascal Maeser & Jennifer Keiser at Swiss TPH in Basel, Switzerland), yeast genetics (Dr. Brigitte Meunier at I2BC, Gif-sur-Yvette, France) and biology of mosquitoes and malarial parasites (Dr Stephanie Blandin at IBMC, Strasbourg).

Project:

The researcher will join the research unit Insect Models of Innate Immunity (M3i), located at the Institute of Molecular and Cellular Biology (IBMC) in Strasbourg, and more particularly the Inserm team 'Immune responses in mosquito vectors'. This group, led by Dr. Stephanie Blandin, is dedicated to the study of the resistance/susceptibility of mosquitoes to pathogens transmitted to humans (parasites and viruses), and to the development of novel strategies to limit disease transmission, including (but not limited to) novel drugs.

The postdoctoral researcher will start by evaluating a series of candidate target genes to decipher the mode of action of antimalarial benzylmenadiones in Plasmodium parasites. In parallel, he/she will look for additional candidates using an affinity-based protein profiling approach coupled with proteomics for which we have already reported a first proofof- concept (Cichocki B. et al., JACSAu 2021, 1(5):669-689. doi: 10.1021/jacsau.1c00025). The candidate should be ready to come up with new models, and to develop relevant assays to test them. Main activities: - Parasitology: Plasmodium falciparum culture (both asexual and gametocytes), parasite enrichment, transfection, assays to measure parasite sensitivity and resistance to drugs, establishment of new assays. - Molecular Biology: construction of plasmids for CRISPR/Cas9 and Selection-Linked Integration (SLI) to generate knockout, overexpression and allele replacement of putative target genes, validation of cassette insertion... - Affinity-Based Protein Profiling to identify new benzylmenadione targets in parasites - Reporting of results in electronic lab-book & lab meetings, attendance to conferences, writing manuscripts. - Supervision of students (recommended) 

Activities and experience:

PhD degree required

We are looking for a highly motivated, and creative candidate with a strong background in parasitology (fundamental criteria). Additional expertise in drug discovery, molecular biology and/or proteomics would be appreciated. The ideal candidate will have a proven track record of scientific excellence, very good communication and writing skills as well as a strong commitment to experimental work. The candidate should be also able to perform independent research and will be encouraged to make use of the expertise and facilities of partners whenever necessary. Knowledge of the French language is not required. Thorough knowledge of English, both oral and written, is mandatory. 

Application:

Application deadline : 27/01/2023

Application e-mail : bstevenin (at) unistra.fr

pdfCALL_FOR_POST-DOC_ROSaction2022.pdf

Friday, 16 December 2022

    PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France  A renewable 1-year postdoctoral...

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Friday, 03 June 2022

  PhD Position in Single Particle Imaging of P. falciparum Knobs Project Leader Prof. Dr. Michael Lanzer (Heidelberg University Hospital, Centre for Infectious Diseases,...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

PROGRAMME DE FORMATION

Programme Doctoral International

Workshops de formation

ACTUALITÉS

Actualités du LabEx
Autres actualités

 

CONTACT

Project Manager: Yoann MILLERIOUX
Contact

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