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Alliance Française contre les Maladies Parasitaires

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

Monday, 14 November 2022

[Communiqué] Gerald Spaeth, chef de l'unité "Parasitologie moléculaire et signalisation" à L'institut pasteur Paris, a obtenu une subvention Synergy du Conseil européen de la...

Monday, 02 November 2015

The Nobel Prize in Medicine 2015 was awarded to researchers in epidemiology : William Campbell (Ireland), Satoshi Omura (Japan) and Youyou Tu (China). They were rewarded for their work against...

Home PIs Philippe Bastin

 

  Philippe Bastin

 

Philippe BASTIN

Information
microscope Trypanosome Cell Biology Unit 
location Paris, Institut Pasteur
orcid 0000-0002-3042-8679 
email This email address is being protected from spambots. You need JavaScript enabled to view it.
website https://research.pasteur.fr/en/team/trypanosome-cell-biology/
twitter @BastinLab_Paris 

Scientific interests and projects

The Trypanosome Cell Biology Unit fits perfectly with the 4 major scientific topics highlighted by the ParaFrap consortium:

• Post-genomic data exploration: The unit is studying the function of various genes in trypanosomes, especially at the level of the cytoskeleton, using a collection of tools such as inducible RNAi, double knockout, gene replacement or Cas9/Cas13 approaches. This is done at the level of parasites in culture but also during infection in tsetse flies or in mice.

• Mechanisms of pathogenesis: Thanks to its own tsetse fly breeding colony, the unit can ask questions through the full life cycle of African trypanosomes and importantly it can study the infection via the natural route that is the bite of the tsetse fly.

• Parasite molecular and cellular biology: The unit is well known for cell biology, especially in the context of cell movement, protein trafficking and organelle function, once again in in vitro and in vivo contexts.

• Towards new intervention strategies against parasitic pathogens: The work carried out in the field in collaboration with the IRD and partners in Africa has significant potential for the diagnosis of gambiense HAT and could change the way both patient treatment and follow-up is carried out. It could be very significant for the WHO programme of elimination of the disease

Top 5 publications of the last 5 years

1. Bertiaux, E., Morga, B., Blisnick, T., Rotureau, B., and Bastin, P. (2018). A Grow-and-Lock Model for the Control of Flagellum Length in Trypanosomes. Curr Biol 28, 3802-3814 e3803. doi: 10.1016/j.cub.2018.10.031

2. Bonnefoy, S., Watson, C.M., Kernohan, K.D., Lemos, M., Hutchinson, S., Poulter, J.A., Crinnion, L.A., Berry, I., Simmonds, J., Vasudevan, P., O'Callaghan, C., Hirst, R.A., Rutman, A., Huang, L., Hartley, T., Grynspan, D., Moya, E., Li, C., Carr, I.M., Bonthron, D.T., Leroux, M., Care4Rare Canada, C., Boycott, K.M., Bastin, P., and Sheridan, E.G. (2018). . Am J Hum Genet 103, 727-739. doi: 10.1016/j.ajhg.2018.10.003

3. Bertiaux, E., Mallet, A., Fort, C., Blisnick, T., Bonnefoy, S., Jung, J., Lemos, M., Marco, S., Vaughan, S., Trepout, S., Tinevez, J.Y., and Bastin, P. (2018). Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum. J Cell Biol 217, 4284-4297. doi: 10.1083/jcb.201805030

4. Calvo-Alvarez, E., Cren-Travaille, C., Crouzols, A., and Rotureau, B. (2018). A new chimeric triple reporter fusion protein as a tool for in vitro and in vivo multimodal imaging to monitor the development of African trypanosomes and Leishmania parasites. Infect Genet Evol 63, 391-403. doi: 10.1016/j.meegid.2018.01.011

5. Capewell, P., Cren-Travaille, C., Marchesi, F., Johnston, P., Clucas, C., Benson, R.A., Gorman, T.A., Calvo-Alvarez, E., Crouzols, A., Jouvion, G., Jamonneau, V., Weir, W., Stevenson, M.L., O'Neill, K., Cooper, A., Swar, N.K., Bucheton, B., Ngoyi, D.M., Garside, P., Rotureau, B., and MacLeod, A. (2016). The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. Elife 5:e17716. doi: 10.7554/eLife.17716

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Friday, 16 December 2022

    PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France  A renewable 1-year postdoctoral...

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Friday, 03 June 2022

  PhD Position in Single Particle Imaging of P. falciparum Knobs Project Leader Prof. Dr. Michael Lanzer (Heidelberg University Hospital, Centre for Infectious Diseases,...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

PROGRAMME DE FORMATION

Programme Doctoral International

Workshops de formation

ACTUALITÉS

Actualités du LabEx
Autres actualités

 

CONTACT

Project Manager: Yoann MILLERIOUX
Contact

Twitter Social Icon Rounded Square Color @ParaFrap #ParaFrap

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