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Alliance Française contre les Maladies Parasitaires

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

Monday, 14 November 2022

[Communiqué] Gerald Spaeth, chef de l'unité "Parasitologie moléculaire et signalisation" à L'institut pasteur Paris, a obtenu une subvention Synergy du Conseil européen de la...

Monday, 02 November 2015

The Nobel Prize in Medicine 2015 was awarded to researchers in epidemiology : William Campbell (Ireland), Satoshi Omura (Japan) and Youyou Tu (China). They were rewarded for their work against...

Home PIs Nicolas Blanchard

 

  Nicolas Blanchard

Nicolas BLANCHARD

Information
microscope Toulouse Institute for Infectious and Inflammatory Diseases 
team EPIIC: Eukaryotic Pathogens: Inflammation, T cell Immunity and Chemoresistance 
location Toulouse
orcid 0000-0002-4924-2161 
email This email address is being protected from spambots. You need JavaScript enabled to view it.
website https://www.infinity.inserm.fr/en/research-teams/team-8-n-blanchard/

Scientific interests and projects

General scientific interests
We study immune responses to Toxoplasma and Plasmodium infections, with a major interest on the implication of T cell responses in host protection and immunopathology. We focus on the molecular determinants of antigen presentation and T cell immunity to these two apicomplexan intracellular parasites.
More specifically, using mouse models of Toxoplasma infection, we have dissected the molecular bases of tachyzoite antigen processing and presentation by macrophages and DC. We have recently established that MHC I presentation of tachyzoite antigens by neurons is critical for durable parasite control in the brain during chronic toxoplasmosis. Another outcome of this work was to create a unique experimental system to study latency and encephalitis in the widely used C57BL/6 mouse model.
In the context of malaria infection, we have profiled the first malaria MHC class II immunopeptidome (i.e. the repertoire of peptides presented by MHC II on the surface of DC). We have shed light on the deleterious role of a subset of conventional DC (cDC1) in driving pathogenic CD4 T cell responses during severe malaria.

We foresee two activities within the Parafrap consortium:
1- in the context of chronic toxoplasmosis, elucidate how cyst-containing neurons, possibly via specific effectors, evade CD8 T cell recognition to allow the establishment of latency.

2- implement a ‘forward vaccinology’ approach based on Plasmodium falciparum immunopeptidome characterization. The goal is to identify and prioritize candidate antigens for a blood stage malaria vaccine.

Top 5 publications of the last 5 years

1. Salvioni A, Belloy M, Lebourg A, Bassot E, Cantaloube-Ferrieu V, Vasseur V, Blanié S, Liblau RS, Suberbielle E, Robey EA, Blanchard N. Robust control of a brain-persisting parasite through MHC I presentation by infected neurons. Cell Reports 2019 Jun 11;27(11):3254-3268.e8. doi: 10.1016/j.celrep.2019.05.051.

2. Bonnart C, Feuillet G, Vasseur V, Cénac N, Vergnolle N*, Blanchard N* (* = co-senior). Toxoplasma gondii infection promotes gut inflammation through Protease Activated Receptor 2 independently from IFNγ and TNFα. Parasite Immunol 2017 Nov;39(11). doi: 10.1111/pim.12489.

3. Draheim M, Wlodarczyk MF, Crozat K, Saliou JM, Alayi TD, Tomavo S, Hassan A, Salvioni A, Demarta-Gatsi C, Sidney J, Sette A, Dalod A, Berry A, Silvie O, Blanchard N. Profiling MHC II immunopeptidome of blood stage malaria reveals that cDC1 control the functionality of parasite-specific CD4 T cells. EMBO Mol Med 2017 Sep 21. pii: e201708123. doi: 10.15252/emmm.201708123.

4. Cebrian I, Croce C, Guerrero NA, Blanchard N*, Mayorga LS*. (* = co-senior). Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells. EMBO Rep. 2016 Dec;17(12):1753-1765. doi: 10.15252/embr.201642358.

5. Lopez J, Bittame A, Massera C, Vasseur V, Effantin G, Valat A, Buaillon C, Allart S, Fox BA, Rommereim LM, Bzik DJ, Schoehn G, Weissenhorn W, Dubremetz JF, Gagnon J, Mercier C, Cesbron-Delauw MF, Blanchard N. Intravacuolar membranes regulate CD8 T cell recognition of membrane-bound Toxoplasma gondii protective antigen. Cell Reports 2015 Dec 15, 13, 1–14. doi: 10.1016/j.celrep.2015.11.001.
Friday, 16 December 2022

    PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France  A renewable 1-year postdoctoral...

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Friday, 03 June 2022

  PhD Position in Single Particle Imaging of P. falciparum Knobs Project Leader Prof. Dr. Michael Lanzer (Heidelberg University Hospital, Centre for Infectious Diseases,...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

PROGRAMME DE FORMATION

Programme Doctoral International

Workshops de formation

ACTUALITÉS

Actualités du LabEx
Autres actualités

 

CONTACT

Project Manager: Yoann MILLERIOUX
Contact

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