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Alliance Française contre les Maladies Parasitaires

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

Monday, 14 November 2022

[Communiqué] Gerald Spaeth, chef de l'unité "Parasitologie moléculaire et signalisation" à L'institut pasteur Paris, a obtenu une subvention Synergy du Conseil européen de la...

Monday, 02 November 2015

The Nobel Prize in Medicine 2015 was awarded to researchers in epidemiology : William Campbell (Ireland), Satoshi Omura (Japan) and Youyou Tu (China). They were rewarded for their work against...

Home PIs Isabelle Tardieux

 

  Isabelle Tardieux

 

Isabelle TARDIEUX

Information
microscope Institute of Advanced Biosciences 
team Biomechanics of Host-Apicomplexa Parasite Interactions 
location Grenoble
orcid 0000-0002-5677-7463 
email This email address is being protected from spambots. You need JavaScript enabled to view it.
website https://iab.univ-grenoble-alpes.fr/...
twitter @TardieuXlab 

Scientific interests and projects

The team has a long lasting interest in combining molecular genetics and cell biology approaches to interrogate how forces and membrane dynamics co-operate during the obligate process of metazoan cell invasion by the Apicomplexa Toxoplasma gondii protozoan parasite. To this end, we have developed state-of-the art high-speed/high-resolution live imaging in conjunction with image processing and kinematic modeling of invading T. gondii tachyzoites. The team has more recently implemented in the lab force microscopy coupled with live fluorescent and super resolution microscopy and introduce nanoprobes/biosensors to also explore how forces can be generated by the free parasites to achieve exceptionally fast gliding in 2D & 3D micro-environments. Additional expertise including precision microfluidics and microfluidics-based micro-patterning, biomimetic and synthetic membrane systems, proteomics and structural biology has been recently achieved in the team, hence providing an ideal position at the interface between cell biology and biophysics to tackle down the yet unknown biomechanical properties of the Toxoplasma and their contribution to parasite fitness. In the context of ParaFrap, we plan continuing/starting to investigate in priority:

1- How the tachyzoite-derived forces coordinate with the host cell surface dynamic biomechanical properties during active invasion,

2- How the tachyzoite-derived forces cope with the parasite/parasite’ organelle deformability to ensure safe motion?

3- How physiologically relevant mechanical constraints could impact the nuclear compartment properties of T. gondii zoites with a focus on chromatin organization and gene expression? This particular research axis results from a tight collaboration with the the ParaFrap member (MH. Hakimi and team).

Top 5 publications of the last 5 years

1. Pavlou G, Milon G, Tardieux I. Intracellular protozoan parasites: living probes of the host cell surface molecular repertoire. Curr Opin Microbiol. 2019 Jul 23;52:116-123. Invited Review. PMID:31349210. doi: 10.1016/j.mib.2019.06.007.

2. Pavlou G, Biesaga M, Touquet B, Lagal V, Balland M, Dufour A, Hakimi MA, Tardieux I. Toxoplasma Parasite Twisting Motion Mechanically Induces Host Cell Membrane Fission to Complete Invasion within a Protective Vacuole. Cell Host Microbe. 2018 Jul 11;24(1):81-96.e5. Epub 2018 Jun 28. PMID: 30008293. doi: 10.1016/j.chom.2018.06.003

3. Tardieux I, Baum J. Reassessing the mechanics of parasite motility and host-cell invasion. J Cell Biol. 2016 Aug 29;214(5):507-15. Invited Review. PMID: 27573462. doi: 10.1083/jcb.201605100. 

4. Bichet M, Touquet B, Gonzalez V, Florent I, Meissner M, Tardieux I. Genetic impairment of parasite myosin motors uncovers the contribution of host cell membrane dynamics to Toxoplasma invasion forces. BMC Biol. 2016 Nov 9;14(1):97. PMID: 27829452. doi: 10.1186/s12915-016-0316-8

5. Bichet M, Joly C, Henni AH, Guilbert T, Xémard M, Tafani V, Lagal V, Charras G, Tardieux I. The toxoplasma-host cell junction is anchored to the cell cortex to sustain parasite invasive force. BMC Biol. 2014 Dec 31;12:773. PMID: 25551479. doi: 10.1186/s12915-014-0108-y. 
Friday, 16 December 2022

    PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France  A renewable 1-year postdoctoral...

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Friday, 03 June 2022

  PhD Position in Single Particle Imaging of P. falciparum Knobs Project Leader Prof. Dr. Michael Lanzer (Heidelberg University Hospital, Centre for Infectious Diseases,...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

PROGRAMME DE FORMATION

Programme Doctoral International

Workshops de formation

ACTUALITÉS

Actualités du LabEx
Autres actualités

 

CONTACT

Project Manager: Yoann MILLERIOUX
Contact

Twitter Social Icon Rounded Square Color @ParaFrap #ParaFrap

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