Image

Alliance Française contre les Maladies Parasitaires

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

Monday, 14 November 2022

[Communiqué] Gerald Spaeth, chef de l'unité "Parasitologie moléculaire et signalisation" à L'institut pasteur Paris, a obtenu une subvention Synergy du Conseil européen de la...

Monday, 02 November 2015

The Nobel Prize in Medicine 2015 was awarded to researchers in epidemiology : William Campbell (Ireland), Satoshi Omura (Japan) and Youyou Tu (China). They were rewarded for their work against...

Home PIs Elisabeth Davioud-Charvet

 

  E Davioud Charvet

 

Elisabeth
DAVIOUD-CHARVET

Information
microscope Laboratoire d'Innovation Moléculaire et Applications (LIMA) 
team Team "bio(IN)organic & medicinal chemistry" 
location Strasbourg
orcid 0000-0001-7026-4034 
email This email address is being protected from spambots. You need JavaScript enabled to view it.
website http://lima.unistra.fr/cbm/
twitter @redoxLCBM 

Scientific interests and projects

The spread of drug resistance in parasites jeopardises recent progress to fight malaria. Chagas’ disease and schistosomiasis are neglected tropical parasitic diseases that are considered as public health top priorities. The expertise of the research team in redox medicinal chemistry is applied to the synthesis of ‘subversive substrates’ of NAD(P)H-dependent oxidoreductases, with the aim to develop antiparasitic agents and to identify new therapeutic targets. Our interdisciplinary activity spans from the synthesis (inhibitors, redox-cyclers, metabolites, ratiometric fluorescent probes sensitive to pH and redox gradients, labelled tools for metabol- & proteo-omics) to enzymology and understanding of the mechanisms of action in living parasites. Among our recent major achievements, we showed that, depending on their chemical substitution pattern, 3-benzyl-menadione derivatives, displayed potent antiparasitic activities, both in vitro and in vivo, against Plasmodium spp., Trypanosoma cruzi, or Schistosoma mansoni worms, induced specific phenotypic effects, with no obvious sign of toxicity in mice and in G6PD-deficient red blood cells.

Our efforts are focused on the optimization of three early leads: the antimalarial plasmodione, a fast acting and transmission blocking agent, the anti-Chagas cruzidione, and the antischistosomal schistodiones. The goal of future collaborative research in ParaFrap is to optimize both early leads and synergistic partners for each disease model, to improve their pharmacokinetic properties and respective antiparasitic activities, to identify the sensitive parasite stages, their modes of action, and to validate the antiparasitic properties of the optimized compounds in vivo and with field parasite isolates. Our overarching aim is i) to select drug-candidates ready for further clinical development, ii) to unravel the modes of action through physicochemical approaches describing the interactions of antiparasitic agents with relevant targets.

Top 5 publications of the last 5 years

1. Feng L., Lanfranchi D. A., Cotos-Munoz L., Cesar Rodo E., Ehrhardt K., Goetz, A.-A., Zimmerman H., Fenaille F., Blandin S., Davioud-Charvet E. (2018) Synthesis of plasmodione metabolites and 13C-enriched plasmodione as chemical tools for drug metabolism investigation. Org. Biomol. Chem. 16, 2647 - 2665. doi: 10.1039/C8OB00227D

2. Krieg R., Jortzik E., Goetz A.-A., Blandin S., Wittlin S., Elhabiri M., Rahbari M., Nuryyeva S., Voigt K., Dahse H.-M., Brakhage A., Beckmann S., Quack T., Grevelding C. G., Pinkerton A. B., Schönecker B., Burrows J., Davioud-Charvet E.,Rahlfs S., Becker K. (2017) Arylmethylamino steroids as novel antiparasitic agents. Nat. Commun. 8:14478. Erratum : Nat Commun. 2019, 10:2997. doi:10.1038/s41467-019-11018-x

3. Ehrhardt, K., Deregnaucourt, C., Goetz, A.-A., Tzanova, T., Pradines, B., Adjalley, S. H., Blandin, S., Bagrel, D., Lanzer, M., Davioud-Charvet, E. (2016) The redox-cycler plasmodione is a fast acting antimalarial lead compound with pronounced activity against sexual and early asexual blood-stage parasites. Antimicrob. Agents Chemother. 60, 5146- 58. doi: 10.1128/AAC.02975-15

4. Cesar Rodo E., Feng L., Jida, M., Ehrhardt K., Bielitza M., Boilevin J., Lanzer M., Williams D. L., Lanfranchi, D. A., Davioud-Charvet, E. (2016) A platform of regioselective methodologies to access to polysubstituted 2-methyl-1,4-naphthoquinones derivatives: scope and limitations. Eur. J. Org. Chem. 11, 1982–1993. doi: 10.1002/ejoc.201600144

5. Bielitza, M., Belorgey, D., Ehrhardt, K., Johann, L., Lanfranchi, D. A., Gallo, V., Schwarzer, E., Mohring, F., Jortzik, E., Williams, D. L., Becker, K., Arese, P., Elhabiri, M., Davioud- Charvet E. (2015) Antimalarial NADPH-consuming redox-cyclers as superior G6PD deficiency copycats. Antioxid. Redox Signal. 22, 1337-51. 10.1089/ars.2014.6047
Friday, 16 December 2022

    PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France  A renewable 1-year postdoctoral...

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Friday, 03 June 2022

  PhD Position in Single Particle Imaging of P. falciparum Knobs Project Leader Prof. Dr. Michael Lanzer (Heidelberg University Hospital, Centre for Infectious Diseases,...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

PROGRAMME DE FORMATION

Programme Doctoral International

Workshops de formation

ACTUALITÉS

Actualités du LabEx
Autres actualités

 

CONTACT

Project Manager: Yoann MILLERIOUX
Contact

Twitter Social Icon Rounded Square Color @ParaFrap #ParaFrap

Cookies settings

×

Functional Cookies

Ce site utilise des cookies pour assurer son bon fonctionnement et ne peuvent pas être désactivés de nos systèmes. Nous ne les utilisons pas à des fins publicitaires. Si ces cookies sont bloqués, certaines parties du site ne pourront pas fonctionner.

Measure of audience

Ce site utilise des cookies de mesure et d’analyse d’audience, tels que Google Analytics et Google Ads, afin d’évaluer et d’améliorer notre site internet.

Interactive Content

Ce site utilise des composants tiers, tels que NotAllowedScript6949bac66b714ReCAPTCHA, Google NotAllowedScript6949bac66aecfMaps, MailChimp ou Calameo, qui peuvent déposer des cookies sur votre machine. Si vous décider de bloquer un composant, le contenu ne s’affichera pas

Social Networks / Videos

Des plug-ins de réseaux sociaux et de vidéos, qui exploitent des cookies, sont présents sur ce site web. Ils permettent d’améliorer la convivialité et la promotion du site grâce à différentes interactions sociales.

Session

Please login to see yours activities!

Other cookies

Ce site web utilise un certain nombre de cookies pour gérer, par exemple, les sessions utilisateurs.