Image

Alliance Française contre les Maladies Parasitaires

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

Monday, 14 November 2022

[Communiqué] Gerald Spaeth, chef de l'unité "Parasitologie moléculaire et signalisation" à L'institut pasteur Paris, a obtenu une subvention Synergy du Conseil européen de la...

Monday, 02 November 2015

The Nobel Prize in Medicine 2015 was awarded to researchers in epidemiology : William Campbell (Ireland), Satoshi Omura (Japan) and Youyou Tu (China). They were rewarded for their work against...

Home PIs Chetan Chitnis

 

  Chetan Chitnis

 

Chetan CHITNIS

Information
microscope Institut Pasteur, Department of Parasites and Insect Vectors 
team Malaria Parasite Biology and Vaccines 
location Paris
orcid 0000-0002-8773-9865 
email This email address is being protected from spambots. You need JavaScript enabled to view it.
website https://research.pasteur.fr/en/team/malaria-parasite-biology-and-vaccines/

Scientific interests and projects

Our laboratory is interested in understanding the biology of blood stage malaria parasites. In particular we are interested in understanding the molecular processes that mediate merozoite egress from schizonts and merozoite invasion of RBCs. We study receptor-ligand interactions that mediate RBC invasion and the signaling processes that regulate steps such as microeneme and rhoptry secretion that are critical for receptor engagement during invasion. Information on parasite proteins involved in invasion will be used to develop multivalent blood stage vaccines for malaria.

In the ParaFrap project, we will explore the signaling mechanisms involved in apical organelle secretion during host cell invasion. In particular we will study the role of second messengers including calcium and cyclic nucleotides, cAMP and cGMP, in regulating microneme secretion. A combination of molecular genetics and phosphoproteomic approaches will be used to decipher the signaling pathways responsible for microneme and rhoptry secretion. In addition, we will identify the critical parasite ligands involved in RBC invasion and try to identify combinations of parasite ligands that can be targeted with antibodies to synergistically block invasion with high efficiency. Such combinations will be developed as blood stage vaccines for P. falciparum malaria. Similar approaches will also be attempted with P. vivax for which short term in vitro invasion assays will be established using enriched reticulocytes and cryopresrved blood stage P. vivax isolates.

Top 5 publications of the last 5 years

1. Singh P., Alaganan A., More K. R., Lorthiois, A, Thiberge S Gorgette O., Guillotte Blisnick M., Guglielmini J., Aguilera S. S., Touqui L., Singh S., Chitnis CE. 2019. Role of a patatinlike phospholipase in Plasmodium falciparum gametogenesis and malaria transmission. Proc. Natl. Acad. Sci., USA. DOI 10.1073/pnas.1900266116.

2. Singh K, Mukherjee P, Shakri AR, Singh A, Pandey GC, Bakshi M, Uppal G, Jena R, Rawat A, Kumar P, Bhardwaj R, Yazdani SS, Hans D, Mehta S, Srinivasan A, Anil K, Madhusudhan RL Patel J, Singh A, Rao R, Gangireddy S, Patil R, Kaviraj S, Singh S, Carter D, Reed S, Kaslow DC, Birkett A, Chauhan VS, Chitnis CE. 2018. A malaria vaccine candidate based on Duffy binding protein elicits strain transcending functional antibodies in a Phase I clinical trial. NPJ Vaccines. 3:48. DOI 10.1038/s41541-018-0083-3.

3. Gupta S, Singh S, Popovici J, Roesch C, Shakri AR, Guillotte-Blisnick M, Huon C, Menard D, Chitnis CE. 2018. Targeting a reticulocyte binding protein and Duffy binding protein to inhibit reticulocyte invasion by Plasmodium vivax. Sci Rep. 8(1):10511. DOI 10.1038/s41598-018-28757-4.

4. Chitnis CE, Mukherjee P, Mehta S, Yazdani SS, Dhawan S, Shakri AR, Bhardwaj R, Gupta PK, Hans D, Mazumdar S, Singh B, Kumar S, Pandey G, Parulekar V, Imbault N, Shivyogi P, Godbole G, Mohan K, Leroy O, Singh K, Chauhan VS. 2015. Phase I clinical trial of a recombinant blood stage vaccine candidate for Plasmodium falciparum malaria based on MSP1 and EBA175. PLoS One. 10(4):e0117820. DOI doi.org/10.1371/journal.pone.0117820

5. Dawn A, Singh S, More KR, Siddiqui FA, Pachikara N, Ramdani G, Langsley G, Chitnis CE. The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes. 2014. PLoS Pathogens. 10(12):e1004520. DOI doi.org/10.1371/journal.ppat.1004520
Friday, 16 December 2022

    PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France  A renewable 1-year postdoctoral...

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Friday, 03 June 2022

  PhD Position in Single Particle Imaging of P. falciparum Knobs Project Leader Prof. Dr. Michael Lanzer (Heidelberg University Hospital, Centre for Infectious Diseases,...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

PROGRAMME DE FORMATION

Programme Doctoral International

Workshops de formation

ACTUALITÉS

Actualités du LabEx
Autres actualités

 

CONTACT

Project Manager: Yoann MILLERIOUX
Contact

Twitter Social Icon Rounded Square Color @ParaFrap #ParaFrap

Cookies settings

×

Functional Cookies

Ce site utilise des cookies pour assurer son bon fonctionnement et ne peuvent pas être désactivés de nos systèmes. Nous ne les utilisons pas à des fins publicitaires. Si ces cookies sont bloqués, certaines parties du site ne pourront pas fonctionner.

Measure of audience

Ce site utilise des cookies de mesure et d’analyse d’audience, tels que Google Analytics et Google Ads, afin d’évaluer et d’améliorer notre site internet.

Interactive Content

Ce site utilise des composants tiers, tels que NotAllowedScript6949ba73104b6ReCAPTCHA, Google NotAllowedScript6949ba730fd85Maps, MailChimp ou Calameo, qui peuvent déposer des cookies sur votre machine. Si vous décider de bloquer un composant, le contenu ne s’affichera pas

Social Networks / Videos

Des plug-ins de réseaux sociaux et de vidéos, qui exploitent des cookies, sont présents sur ce site web. Ils permettent d’améliorer la convivialité et la promotion du site grâce à différentes interactions sociales.

Session

Please login to see yours activities!

Other cookies

Ce site web utilise un certain nombre de cookies pour gérer, par exemple, les sessions utilisateurs.