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Alliance Française contre les Maladies Parasitaires

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

Monday, 14 November 2022

[Communiqué] Gerald Spaeth, chef de l'unité "Parasitologie moléculaire et signalisation" à L'institut pasteur Paris, a obtenu une subvention Synergy du Conseil européen de la...

Monday, 02 November 2015

The Nobel Prize in Medicine 2015 was awarded to researchers in epidemiology : William Campbell (Ireland), Satoshi Omura (Japan) and Youyou Tu (China). They were rewarded for their work against...

Home PIs Artur Scherf

 

  Artur Sherf

 

Artur SCHERF

Information
microscope Biology of Host Parasite Interactions 
location Paris, Institut Pasteur
orcid 0000-0003-2411-3328 
email This email address is being protected from spambots. You need JavaScript enabled to view it.
website https://research.pasteur.fr/en/team/biology-of-host-parasite-interactions/

Scientific interests and projects

The ‘Biology of Host-Parasite Interactions (BIHP)’ Unit, led by Prof Artur Scherf (DRCE CNRS), comprises 4 groups with a research focus on malaria parasite virulence, pathogenesis, liver stage infection and host immune responses to establish the molecular and cellular bases of parasite strategies to successfully complete the life cycle. By integrating a novel humanized mouse model, a rodent malaria model and mosquitoes, our studies address key biological aspects of the different stages of the life cycle development of Plasmodium falciparum and P. berghei.

Activities of team members within ParaFrap:

SCHERF A. has spearheaded the discovery of gene regulatory mechanisms over more than two decades. A main focus is on epigenetic factors that control 3-D spatial organization, transcription and posttranscriptional control of gene regulation with a particular focus on antigenic variation. The team uses routinely a wide array of techniques in literally all stages of the parasite life cycle, including genome-wide approaches such as ChIP-seq and RNA/DNA-seq as well as targeted genome editing. More recently, the team has developed in collaboration with a medicinal chemist (P. Arimondo, Institut Pasteur), distinct epigenetic compounds that kill efficiently multidrug resistant P. falciparum including artemisinin resistant strains and are active against transmission stages. Validation of lead epigenetic compounds using P. falciparum and P. vivax liver stages including hypnozoites, infected mosquitoes and humanized mouse models is an ongoing activity.

MANCIO SILVA L. has a long-term interest in understanding the malaria parasite interaction with hepatocytes and the interventions needed to control malaria disease. She is using rodent malaria models, sophisticated human hepatocyte culture systems and live imaging approaches to study sporozoite invasion and development in hepatocytes with a focus on the role of distinct metabolic states of host cells in infection.

GARCIA S. has a strong expertise on humanized mouse experimentation and has improved this model for studies of P. falciparum with the potential to establish this new model to study P. vivax.

Top 5 publications of the last 5 years

1. Baumgarten S, Bryant JM, Sinha A, Reyser T, Preiser PR, Dedon PC, Scherf A. Transcriptome-wide dynamics of extensive m6A mRNA methylation during Plasmodium falciparum blood-stage development. Nat Microbiol. 2019 Aug 5. doi: 10.1038/s41564-019-0521-7.

2. Mancio-Silva L, Slavic K, Grilo Ruivo MT, Grosso AR, Modrzynska KK, Vera IM, Sales-Dias J, Gomes AR, MacPherson CR, Crozet P, Adamo M, Baena-Gonzalez E, Tewari R, Llinás M, Billker O, Mota MM. Nutrient sensing modulates malaria parasite virulence. Nature. 2017 Jul 13;547(7662):213-216. doi: 10.1038/nature23009.

3. MacPherson C. and A. Scherf. Protospacer Workbench: flexible guide-RNA design for CRISPR applications. Nat. Biotechnol. 2015 Aug;33(8):805-6. doi: 10.1038/nbt.3291. Epub 2015 Jun 29.3

4. Ghorbal M, Gorman M, Macpherson CR, Martins RM, Scherf A, Lopez-Rubio JJ. Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system. Nat Biotechnol. 2014 Jun 1. doi: 10.1038/nbt.2925

5. Zhang Q, Siegel TN, Martins RM, Wang F, Cao J, Gao Q, Cheng X, Jiang L, Hon CC, Scheidig-Benatar C, Sakamoto H, Turner L, Jensen AT, Claes A, Guizetti J, Malmquist NA, Scherf A. Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria. Nature. 2014 Jun 29. (Research Highlights in Nat. Reviews Microbiol) doi: 10.1038/nature13468
Friday, 16 December 2022

    PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France  A renewable 1-year postdoctoral...

Friday, 17 June 2022

[Communiqué] L'équipe du Dr Chetan Chitnis de l’Institut Pasteur, partenaire du LabEx ParaFrap, a étudié le stade sanguin du parasite Plasmodium falciparum, à l’origine de la forme la...

Thursday, 24 March 2016

The Bioscope Group is organizing the Bioscope Summer Courses in Proteomics in June 2016, in Caparica (Lisbon, Portugal), as follows:   June 15th-17th 2016Hands-on course in ultrafast sample...

Friday, 27 January 2023

[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs...

Friday, 03 June 2022

  PhD Position in Single Particle Imaging of P. falciparum Knobs Project Leader Prof. Dr. Michael Lanzer (Heidelberg University Hospital, Centre for Infectious Diseases,...

Monday, 29 February 2016

The SFP (French Society of Parasitology) - SFMM (the French Society of Medical Mycology) annual meeting 2016 will take place in Grenoble from 23 to 25 March 2016. Information and registration on...

Tuesday, 03 January 2023

Le LabEx ParaFrap vous souhaite plein de bonheur, de santé, de science et de succès pour 2023. Première actualité du réseau cette année : les webinaires ParaFrap reprennent en 2023, comme les...

Tuesday, 27 October 2015

The Bioscope Group is organizing the Bioscope Winter Courses in Proteomics in January-February 2016, in Caparica (Lisbon, Portugal), as follows:   January 25th-27th 2016 V Hands-on course in...

PROGRAMME DE FORMATION

Programme Doctoral International

Workshops de formation

ACTUALITÉS

Actualités du LabEx
Autres actualités

 

CONTACT

Project Manager: Yoann MILLERIOUX
Contact

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